Poly-L-glutamic acid and poly-L-lysine: model substances for studying secondary structures of proteins
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منابع مشابه
Poly (L-glutamic acid)-Paclitaxel Conjugates for Cancer Treatment
One of the effective approaches to develop new anticancer drugs is to prepare polymeranticancer drug conjugates. The polymer-anticancer drug conjugates include polymerprotein conjugates, polymer-drug conjugates and supramolecular drug-delivery systems. In 1975, the concept of a polymer-drug conjugate was first proposed by Ringsdorf (Ringsdorf, 1975). In his model, a bioactive anticancer agent w...
متن کاملpH-jump induced -helix folding of poly-l-glutamic acid
pH jumps are a truly biomimetic technique to initiate non-equilibrium dynamics of biomolecules. In this work, the pH jump induced alpha-helix folding of poly-L-glutamic acid is investigated upon proton release from o-nitrobenzaldehyde. The aim of this work is twofold: On the one hand, design criteria of pH jump experiments are discussed, on the other hand, the folding mechanism of poly-L-glutam...
متن کاملEffects of poly-L-lysine on infectious viral nucleic acid.
Infectious ribonucleic acids (IRNA) of Venezuelan equine encephalitis and Eastern equine encephalitis viruses were observed to form noninfectious complexes with a basic polyamino acid, poly-l-lysine. Original infectivity was recovered from the complexes by digestion of the polylysine with Pronase, and partial recovery was effected by treatment with sodium dodecyl sulfate. Infectivity could not ...
متن کاملGenome Sequence of Streptomyces albulus PD-1, a Productive Strain for Epsilon-Poly-l-Lysine and Poly-l-Diaminopropionic Acid
Streptomyces albulus PD-1, a productive strain for epsilon-poly-l-lysine and poly-l-diaminopropionic acid, was isolated from soils. We present the genome sequence of S. albulus PD-1, which may provide abundant information regarding the production of epsilon-poly-l-lysine and poly-l-diaminopropionic acid.
متن کاملThe effect of aliphatic alcohols on the helix-coil transition of poly-L-ornithine and poly-L-glutamic acid.
The helical stability of poly-L-glutamic acid and poly-Lornithine in aqueous alcohol solutions was studied by optical rotatory dispersion and potentiometric titration determinations. It was found that aliphatic alcohols enhance the stability of the helix according to the series methanol < ethanol < I-propanol < I-butanol. The role of secondary and tertiary alcohols was also investigated. Thermo...
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ژورنال
عنوان ژورنال: Biochemistry and Molecular Biology Education
سال: 2000
ISSN: 1470-8175,1539-3429
DOI: 10.1111/j.1539-3429.2000.tb00161.x